DENVER — Peyton Manning joined Brett Favre in the NFL's most exclusive of clubs with his 500th touchdown pass Sunday when the Denver Broncos handed the Arizona Cardinals their first loss, 41-20.
When will Peyton pass Brett?
Manning finished with four TD throws, moving him within five of Favre's record 508.
Manning found tight end Julius Thomas twice in the end zone, including the touchstone touchdown, a 7-yard dart in the first quarter.
Yet, it was wide receiver Demaryius Thomas who had the biggest day for the Broncos (3-1) with eight catches for a team-record 226 yards and two TDs. That beat Shannon Sharpe's mark of 214 yards set against Kansas City in 2002.
Arizona (3-1) lost for the first time and saw quarterback Drew Stanton leave with a possible concussion.
New England 43, Cincinnati 17
FOXBOROUGH, Mass — Tom Brady and the Patriots routed the Bengals and quieted the doubters.
The three-time Super Bowl winner finally looked like a quarterback who has thrown for 50,000 yards in his career as New England dominated the NFL's last unbeaten team, beating Cincinnati 43-17 Sunday night.
Just six days earlier, the Patriots lost to the Kansas City Chiefs 41-14, unleashing criticism that Brady had regressed and lacked talented teammates to help him.
Sunday's win had special significance for Brady, as he became the sixth quarterback to pass the 50,000-yard mark.
Brady threw for a 292 yards after not passing for more than 249 in his first four games, and Stevan Ridley had 113 of the team's 220 yards rushing against a team that had allowed an NFL-low 11 points per game.
Dallas 20, Houston 17
ARLINGTON, Texas — Dan Bailey kicked a 49-yard field goal in overtime after a miss at the end of regulation ended his franchise record streak of made kicks, and the Dallas Cowboys beat the Houston Texans 20-17.
Bailey's kick was set up when Tony Romo threw off his back foot with pressure coming and Dez Bryant made a spectacular leaping catch for 37 yards.
The Cowboys (4-1) won their fourth straight for the first time since 2011 despite blowing a 10-point lead in the fourth quarter.
The Texans (3-2) rallied behind Arian Foster, who had 157 yards rushing and a tying 1-yard score with 41 seconds left in regulation.
Bailey's miss from 53 yards on the final play of regulation ended a franchise record streak of 30 straight made field goals.
San Francisco 22, Kansas City 17
SANTA CLARA, Calif. — Colin Kaepernick threw for 201 yards and a touchdown, Frank Gore ran for 107 yards and the San Francisco 49ers converted a fake punt to beat the Kansas City Chiefs 22-17 on Sunday.
The 49ers (3-2) turned to a trick play on fourth-and-1 from their own 29 early in the fourth quarter, giving a direct snap to Craig Dahl for a 3-yard run up the middle. Kaepernick directed the offence down field, and Phil Dawson kicked a 27-yard field goal with 8:42 to play for the go-ahead score.
Dawson also connected from 55, 52, 35 and 30 yards.
The 49ers held off former franchise quarterback Alex Smith and the Chiefs (2-3) twice in the closing moments. Smith threw for 175 yards and two touchdowns, but Perrish Cox intercepted his overthrown pass to end any chance Kansas City had to rally.
San Diego 31, New York Jets 0
SAN DIEGO — Philip Rivers threw two touchdown passes to Antonio Gates and rookie running back Branden Oliver's big day included his first two NFL touchdowns as the San Diego Chargers beat the hapless New York Jets 31-0 Sunday for their fourth straight win.
The Chargers (4-1) heaped more pain on the Jets (1-4), who lost their fourth straight game and turned to Michael Vick. Vick replaced Geno Smith on New York's first possession of the second half, but wasn't any more effective.
Other than being sacked three times, Rivers had his way with the Jets. He was 20 of 28 for 288 yards and three touchdowns, with one interception.
Buffalo 17, Detroit 14
DETROIT — Dan Carpenter hit a 58-yard field goal with 4 seconds remaining to cap the Buffalo Bills come-from-behind 17-14 win over the Detroit Lions on Sunday.
Kyle Orton, making his debut as the Bills starter, set up the decisive kick by completing a 20-yard pass over the middle to Sammy Watkins as Buffalo (3-2) overcame a 14-0 deficit. It was the eighth game that Orton has won in overtime or when trailing in the fourth quarter.
Orton went 30 of 43 for 308 yards with a 2-yard touchdown pass to Chris Gragg.
The Lions (3-2) were undone by kicker Alex Henery missing all three field-goal attempts, including a 50-yarder wide left with 21 seconds left. Receiver Calvin Johnson and running back Reggie Bush both injured ankles in the loss.
Pittsburgh 17, Jacksonville 9
JACKSONVILLE, Fla. — Brice McCain returned an interception 22 yards for a touchdown, helping the Pittsburgh Steelers overcome a mediocre offensive performance and beat the winless Jacksonville Jaguars 17-9.
McCain stepped in front of receiver Allen Hurns early in the fourth quarter, intercepted rookie Blake Bortles' wobbly sideline pass and went untouched the other way.
New York Giants 30, Atlanta 20
EAST RUTHERFORD, N.J. — First-round draft pick Odell Beckham Jr. made his NFL debut a memorable one, catching a go-ahead 15-yard touchdown pass from Eli Manning with 10:02 left to lead the New York Giants to a 30-20 victory over the Atlanta Falcons.
Fellow rookie Andre Williams scored on a 3-yard run to ignite the second-half rally that saw the Giants (3-2) come from 10-points down to win their third straight game.
Carolina 31, Chicago 24
CHARLOTTE, N.C. — Cam Newton threw two touchdown passes to Greg Olsen and the Carolina Panthers' defence forced four turnovers to overcome a 14-point deficit and defeat the Chicago Bears 31-24.
With the game tied at 24, Carolina's Antoine Cason stripped Matt Forte of the ball and the Panthers' Kawaan Short recovered at Chicago's 23. Six plays later, Newton found Olsen on a slant route for a 6-yard touchdown for the go-ahead score with 2:18 left.
Philadelphia 34, St. Louis 28
PHILADELPHIA — Nick Foles threw two touchdown passes, the defense and special teams each scored, and the Philadelphia Eagles held on for a 34-28 victory over the St. Louis Rams.
The Eagles (4-1) rebounded from a tough loss at San Francisco with a strong all-around performance until the end. Chris Maragos returned a blocked punt for a touchdown, Cedric Thornton recovered a fumble for a score and nearly took another one the distance.
Indianapolis 20, Baltimore 13
INDIANAPOLIS — Andrew Luck threw one touchdown pass and ran for another score and the defense held on late as the Colts beat Baltimore 20-13.
Luck was 32 of 49 for 312 yards with two interceptions, but scored the decisive points on a nifty 13-yard scoring run with 8:56 left in the game.
Indianapolis (3-2) has won three straight. Baltimore (3-2) lost for the first time since Week 1.
Cleveland 29, Tennessee 28
Largest NFL comebacks:
32:
BUF vs. HOU, Jan. 3, 1993
28:
IND vs. KC, Jan. 4, 2014
SF vs. NO, Dec. 7, 1980
26:
BUF vs. IND, Sept. 21, 1997
25:
STL vs, TB, Nov. 8, 1987
CLE vs. TEN, Oct. 5, 2014
NASHVILLE — Brian Hoyer threw a 6-yard touchdown pass to Travis Benjamin with 1:09 left, and the Cleveland Browns rallied from a 25-point deficit in beating the Tennessee Titans 29-28 for their first road win in more than a year.
The Browns (2-2) won a road game for the first time since Sept. 22, 2013, at Minnesota, and they couldn't have made it tougher on themselves as they fell behind 28-3 in the first half. They snapped a seven-game road skid scoring 26 unanswered points, including 16 in the fourth quarter.
New Orleans 37, Tampa Bay 31
NEW ORLEANS — Khiry Robinson's tackle-breaking, 18-yard touchdown run in overtime lifted the New Orleans Saints to a 37-31 victory over the Tampa Bay Buccaneers.
Pierre Thomas caught eight passes out of the backfield for 77 yards and a touchdown. He also rushed for 35 yards and a score to help New Orleans (2-3) overcome Drew Brees' three interceptions — and an 11-point deficit in the fourth quarter.
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